Arbutus Biopharma Corp (NASDAQ: ABUS) today announced the demonstration of five summaries at the European Association for the Study of the Liver (EASL) International Liver CongressTM (ILC).
Summaries presented by Professor Man-Fung Yuen
The synopses encompassed an oral late-breaker validation (Demonstration LBO-2764) by Professor Man-Fung Yuen, D.Sc., M.D., Ph.D., and Deputy Head of Department, Chief of Division of Gastroenterology and Hepatology, Master of Lap Chee, University of Hong Kong. Prof. Cheng is the lead researcher of AB-729’s Phase 1a/1b scientific pilot, designated, “Repeat dosing of the GalNAc-siRNA AB-729 in subjects with chronic hepatitis B results in robust and sustained HBsAg suppression.”
As offered by Professor Yuen, AB-729 endures to validate healthy mean HBsAg decrease across all dosages and medicating interludes with a promising security and acceptability profile, trailed by a constant mesa stage.
Professor Yuen stated, “These statistics endure to validate that AB-729 transports continued and analogous HBsAg lessening across all dosages and dose intermissions. Prominently, AB-729 was usually benign and well borne. I believe these consequences support sustained assessment of AB-729 as a noteworthy progression in the future cure of chronic HBV.”
“The accessible efficiency and security figures for AB-729, prop our opinion that 60 mg every 8 weeks is an appropriate dosage to move onward in our imminent Phase 2a scientific assessments,” stated Gaston Picchio, Ph.D., Chief Development Officer at Arbutus.
Picchio added, “In adding, while only founded on 3/5 evaluable subjects, long-term treating with AB-729 confirmed augmented HBV-specific immune reactions. It provided provision for combination therapy counting immunomodulatory agents.”
AB-729 ILCTM 2021 Poster Demonstrations
Poster, 2823 Reticence of hepatitis B exterior antigen in long-lasting hepatitis B topics by RNA meddling therapeutic AB-729, is escorted by upregulation of HBV-specific T cell start indicators. The bestowing writer, Dr. Emily Thi, Ph.D., Director, Immunobiology and Biomarkers Research, Arbutus Biopharma Corp.
AB-729 encouraged decreases in HBsAg are related to amplified HBV-specific resistant replies in 3/5 evaluable themes. These upsurges in HBV-specific resistant reactions were supplemented by mild to moderate ALT raises. These are the first consequences in a background of small interfering RNA (siRNA) treatment, reinforcing the theory that long-term HBV antigen overpowering can endorse resistant reawakening in HBV topics.